Structure and Function of GPCRs by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030245917
Publisher: Springer International Publishing

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Table 3The structure of the compounds synthesized with antihistamine H1 activity

Comp

R

H1-receptor blocking activity (IC50 μg/mL)a

198

H

–

199

CH2CN

–

200

(CH2)2CH2NH2

–

201

(CH2)2NHC(=O)C6H4-2-NO2

0.157 ± 0.06

202

(CH2)2NHC(=O)C6H4-3-NO2

0.19 ± 0.06

203

(CH2)2NHC(=O)C6H4-4-NO2

0.41 ± 0.02

204

(CH2)2NHC(=O)C6H4-2-NH2

0.36 ± 0.19

205

(CH2)2NHC(=O)C6H4-3-NH2

0.24 ± 0.048

206

(CH2)2NHC(=O)C6H4-4-NH2

0.51 ± 0.05

207

(CH2)2NHC(=O)C6H4-2-CH3

0.11 ± 0.08

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